Fig. 1 · Structure
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L 748780
Cyclooxygenase-2 Inhibitor
L 748780 is a selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating an IC50 of 0.5 μM for COX-2 and greater than 100 μM for COX-1, indicating a high degree of specificity. This compound is utilized in research to explore COX-2's role in inflammatory processes and related diseases. Its potent inhibition makes it valuable for studies investigating the therapeutic potential of COX-2 suppression in conditions such as arthritis and cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 168086-64-4 |
| Applications | Cyclooxygenase-2 Inhibitor |
| Formula | C19H14Cl3NO4 |
| Molecular Weight | 426.68 |
| SMILES | O=C(CC1=C(C)N(C(C2=C(Cl)C=C(Cl)C=C2Cl)=O)C3=C1C=C(C=C3)OC)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.