Fig. 1 · Structure
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L-778123 dihydrochloride
FPTase/GGPTase-I Inhibitor
L-778123 dihydrochloride is a potent dual inhibitor of farnesyltransferase (FPTase) and geranylgeranyltransferase-I (GGPTase-I), exhibiting IC50 values of 2 nM and 98 nM, respectively. This compound is valuable for research applications focused on protein prenylation pathways, contributing to the understanding of cellular processes such as signal transduction and oncogenesis. L-778123 dihydrochloride’s selective inhibition of these enzymes makes it a useful tool for investigating the role of lipid modifications in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 183499-56-1 |
| Applications | FPTase/GGPTase-I Inhibitor |
| Formula | C22H22Cl3N5O |
| Molecular Weight | 478.80 |
| SMILES | N#CC1=CC=C(CN2C(CN3CC(N(C4=CC=CC(Cl)=C4)CC3)=O)=CN=C2)C=C1.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.