Fig. 1 · Structure
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L-778123
FPTase/GGPTase-I Iinhibitor
L-778123 is a dual inhibitor of farnesyltransferase (FPTase) and geranylgeranyltransferase-I (GGPTase-I), exhibiting IC50 values of 2 nM and 98 nM, respectively. This compound effectively interferes with the post-translational modification of proteins, impacting cellular processes such as growth, proliferation, and differentiation. L-778123 is utilized in research related to cancer biology and the study of diseases associated with aberrant protein prenylation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 183499-57-2 |
| Applications | FPTase/GGPTase-I Iinhibitor |
| Formula | C22H20ClN5O |
| Molecular Weight | 405.88 |
| SMILES | N#CC1=CC=C(CN2C(CN3CC(N(C4=CC=CC(Cl)=C4)CC3)=O)=CN=C2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.