Fig. 1 · Structure
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L 858051 dihydrochloride
Adenylyl Cyclase Activator
L 858051 dihydrochloride is a potent adenylyl cyclase activator that directly stimulates the production of cyclic AMP (cAMP) in cells. This compound significantly elevates intracellular cAMP levels, inducing robust activation of recombinant cyclic nucleotide-gated channels and enhancing L-type Ca2+ currents in adult rat ventricular myocytes. Additionally, it has been shown to increase total phosphodiesterase activities, providing valuable insights into subsarcolemmal cAMP dynamics and compartmentation within cardiac cells. L 858051 dihydrochloride is a useful reagent for exploring cAMP-related signaling pathways in cardiovascular research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 115116-37-5 |
| Applications | Adenylyl Cyclase Activator |
| Formula | C29H50Cl2N2O7 |
| Molecular Weight | 609.62 |
| Synonyms | 7DMB-Forskolin |
| SMILES | O=C(O[C@H]1[C@@H](O)[C@@]2([H])C(C)(C)CC[C@H](O)[C@]2(C)[C@]3(O)[C@]1(C)O[C@@](C)(C=C)CC3=O)CCCN4CCN(C)CC4.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.