Fig. 1 · Structure
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L 858051
Adenylyl Cyclase Stimulator
L 858051 is an adenylyl cyclase stimulator that enhances intracellular cAMP levels through direct activation of adenylyl cyclase. This compound effectively induces non-selective, Mg2+-sensitive currents in recombinant cyclic nucleotide-gated channels and maximally stimulates L-type Ca2+ currents in adult rat ventricular myocytes. Additionally, L 858051 increases total PDE3 and PDE4 activities in these cells, demonstrating effects that are not influenced by PKA inhibition. It is a valuable tool for investigating subsarcolemmal cAMP dynamics and compartmentation in cardiac myocytes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 110452-75-0 |
| Applications | Adenylyl Cyclase Stimulator |
| Formula | C29H48N2O7 |
| Molecular Weight | 536.70 |
| Synonyms | 7DMB-Forskolin free base |
| SMILES | O=C(CCCN1CCN(CC1)C)O[C@H]2[C@H]([C@]3(C(C)(CC[C@@H]([C@@]3([C@@]4([C@@]2(O[C@@](C=C)(CC4=O)C)C)O)C)O)C)[H])O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.