L-Asparagine-13C4,15N2,d8 is a stable isotope-labeled form of the amino acid L-Asparagine, enriched with carbon-13 and nitrogen-15 isotopes. This compound plays a critical role in cancer research, particularly in the study of leukemia, as it serves as a substrate for the enzyme L-Asparaginase, which depletes asparagine and glutamine levels in the body. By inhibiting RNA and DNA synthesis in lymphoblasts, L-Asparaginase induces apoptosis in leukemic cells, making L-Asparagine-13C4,15N2,d8 a valuable tool for understanding mechanisms of cancer cell growth and for investigating childhood acute lymphoblastic leukemia.
L-Asparagine-13C4,15N2,d8 is a stable isotope-labeled form of the amino acid L-Asparagine, enriched with carbon-13 and nitrogen-15 isotopes. This compound plays a critical role in cancer research, particularly in the study of leukemia, as it serves as a substrate for the enzyme L-Asparaginase, which depletes asparagine and glutamine levels in the body. By inhibiting RNA and DNA synthesis in lymphoblasts, L-Asparaginase induces apoptosis in leukemic cells, making L-Asparagine-13C4,15N2,d8 a valuable tool for understanding mechanisms of cancer cell growth and for investigating childhood acute lymphoblastic leukemia.
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