L-Asparagine-13C4,15N2 monohydrate is a stable isotope-labeled form of the amino acid L-Asparagine, incorporating four carbon-13 and two nitrogen-15 atoms. This compound serves as a key substrate for the enzyme L-Asparaginase, which is crucial in the treatment of leukemia by depleting asparagine levels and inhibiting cellular protein biosynthesis, particularly in lymphoblasts. Through asparagine elimination from the plasma, L-Asparaginase triggers suppression of RNA and DNA synthesis, leading to apoptosis in cancer cells, especially those with low expression of asparagine synthetase. L-Asparagine monohydrate can also serve as a valuable biomarker for research involving childhood acute lymphoblastic leukemia.
L-Asparagine-13C4,15N2 monohydrate is a stable isotope-labeled form of the amino acid L-Asparagine, incorporating four carbon-13 and two nitrogen-15 atoms. This compound serves as a key substrate for the enzyme L-Asparaginase, which is crucial in the treatment of leukemia by depleting asparagine levels and inhibiting cellular protein biosynthesis, particularly in lymphoblasts. Through asparagine elimination from the plasma, L-Asparaginase triggers suppression of RNA and DNA synthesis, leading to apoptosis in cancer cells, especially those with low expression of asparagine synthetase. L-Asparagine monohydrate can also serve as a valuable biomarker for research involving childhood acute lymphoblastic leukemia.
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