Fig. 1 · Structure
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L-Asparagine-13C4,15N2
13C and 15N-Labeled L-Aspartic acid
L-Asparagine-13C4,15N2 is a stable isotopically labeled derivative of L-Asparagine, incorporating 13C and 15N isotopes. This compound serves as a substrate for L-Asparaginase, an anti-leukemic enzyme that depletes asparagine and glutamine, thereby inhibiting protein biosynthesis and inducing apoptosis in lymphoblasts. Its ability to selectively target cancer cells with low asparagine synthetase expression makes L-Asparagine-13C4,15N2 a valuable tool in research applications, particularly in the study of childhood acute lymphoblastic leukemia, where it can act as a biomarker and sensor.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 781596-75-6 |
| Applications | 13C and 15N-Labeled L-Aspartic acid |
| Formula | 13C4H815N2O3 |
| Molecular Weight | 138.08 |
| Synonyms | (-)-Asparagine-13C4,15N2; Asn-13C4,15N2; Asparamide-13C4,15N2 |
| SMILES | [15NH2][13C]([13CH2][13C@H]([15NH2])[13C](O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.