L-p-Boronophenylalanine is a boron-containing substrate that selectively targets L-type amino acid transporters (LAT1 and LAT2). By competing with natural amino acids, it facilitates the uptake of boron into tumor cells, making it useful in boron neutron capture therapy (BNCT). Upon exposure to thermal neutrons, boron-10 undergoes a nuclear reaction that generates high-energy alpha particles, effectively inducing cell death in cancer cells, particularly in glioblastoma and anaplastic astrocytoma, while minimizing damage to adjacent healthy tissues.
L-p-Boronophenylalanine is a boron-containing substrate that selectively targets L-type amino acid transporters (LAT1 and LAT2). By competing with natural amino acids, it facilitates the uptake of boron into tumor cells, making it useful in boron neutron capture therapy (BNCT). Upon exposure to thermal neutrons, boron-10 undergoes a nuclear reaction that generates high-energy alpha particles, effectively inducing cell death in cancer cells, particularly in glioblastoma and anaplastic astrocytoma, while minimizing damage to adjacent healthy tissues.
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