Fig. 1 · Structure
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L82
DNA Lig1 Inhibitor
L82 is a selective uncompetitive inhibitor of DNA ligase 1 (hLig1) with an IC50 value of 12 μM. This compound exhibits anti-proliferative activity against breast cancer cells, making it a valuable tool for studying DNA repair mechanisms and tumor progression. Researchers may utilize L82 in investigations of cancer biology and therapeutic targeting of DNA ligase pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 329227-30-7 |
| Applications | DNA Lig1 Inhibitor |
| Formula | C11H8ClN5O4 |
| Molecular Weight | 309.67 |
| SMILES | O=C1NN=CC(N/N=C/C2=CC=C(C([N+]([O-])=O)=C2)O)=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.