Documents & Downloads

LAB687

MTP Inhibitor

LAB687 is a potent inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 of 0.9 nM in reducing apoB secretion from HepG2 cells. Additionally, LAB687 acts as an antagonist of the Smoothened (Smo) receptor, with IC50 values of 2.48 μM in mouse and 3.42 μM in human Smo. This compound effectively lowers triglyceride and LDL cholesterol levels while inhibiting the Hedgehog signaling pathway, making it a valuable tool in cardiovascular and cancer research.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	256397-11-2
Applications	MTP Inhibitor
Formula	C₂₆H₂₃F₃N₂O₃
Molecular Weight	468.47
SMILES	COC(N[C@@H]1CC2=CC=C(C=C2C1)NC(C(C=CC=C3C)=C3C4=CC=C(C(F)(F)F)C=C4)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.