- Cat. No.
- A12778
Lomitapide
Lomitapide is a potent microsomal triglyceride transfer protein (MTP) inhibitor.
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- Cat. No.
- A12278
PF-02575799
PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77±0.29 nM.
In stock View Details -
- Cat. No.
- A13287
Implitapide
Synonyms: AEGR 427
Implitapide (AEGR 427) is a microsomal triglyceride transfer protein (MTP) inhibitor.
In stock View Details -
- Cat. No.
- A16600
Lomitapide mesylate
Synonyms: AEGR-733 mesylate; AEGR733; BMS-201038 mesylate; BMS 201038
Lomitapide mesylate(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.
In stock View Details -
- Cat. No.
- A44273
LAB687
LAB687 is a potent inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 of 0.9 nM in reducing apoB secretion from HepG2 cells. Additionally, LAB687 acts as an antagonist of the Smoothened (Smo) receptor, with IC50 values of 2.48 μM in mouse and 3.42 μM in human Smo. This compound effectively lowers triglyceride and LDL cholesterol levels while inhibiting the Hedgehog signaling pathway, making it a valuable tool in cardiovascular and cancer research.
Out of stock
All 3 sizes -
- Cat. No.
- A53708
MTP3 ligand-1
MTP3 ligand-1 is a ligand for the MTP3 target involved in PROTAC-mediated degradation. This compound facilitates the degradation of MYC through the PROTAC MTP3 degrade-1 system, enabling targeted protein degradation studies. MTP3 ligand-1 is essential for elucidating MYC's role in various biological processes and its implications in cancer research and therapeutic development.
Out of stock
All 3 sizes -
- Cat. No.
- A76639
CP-346086
CP-346086 is a potent inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 of 2.0 nM for both human and rodent MTP. This compound effectively reduces plasma cholesterol and triglyceride levels in vivo, making it a valuable tool for studying lipid metabolism and cardiovascular diseases. Its pharmacological properties position CP-346086 as a significant reagent for research into dyslipidemia and related metabolic conditions.
In stock View Details -
- Cat. No.
- A76640
SLX-4090
SLX-4090 is an orally active inhibitor of the microsomal triglyceride transfer protein (MTP), exhibiting an IC50 of 8.0 nM. This compound primarily targets enterocytes, making it a valuable tool for investigating dyslipidemia. Its ability to modulate lipid metabolism positions SLX-4090 as a significant reagent for research into metabolic disorders and related therapeutic strategies.
In stock View Details -
- Cat. No.
- A76641
Usistapide
Synonyms: JNJ-16269110
Usistapide is a potent inhibitor of microsomal triglyceride transfer protein (MTP). It exhibits significant biological activity in the modulation of lipid metabolism and is primarily utilized in research focused on obesity and associated metabolic disorders. This compound provides valuable insights into therapies targeting lipid absorption and transport.
In stock View Details -
- Cat. No.
- A76642
Dirlotapide
Synonyms: CP742033; Slentrol
Dirlotapide is a selective inhibitor of microsomal triglyceride transfer protein (MTP), primarily targeting lipid metabolism pathways. This compound demonstrates key biological activity in promoting weight loss by modulating triglyceride transfer and absorption. Dirlotapide is applicable in research focused on obesity and metabolic disorders, offering insights into lipid regulation and potential therapeutic strategies.
In stock View Details -
- Cat. No.
- A76643
CP-346086 dihydrate
CP-346086 dihydrate is a potent inhibitor of microsomal triglyceride transfer protein (MTP), with an IC50 of 2.0 nM for both human and rodent MTP. This compound effectively reduces plasma cholesterol and triglyceride levels in vivo, making it a valuable tool for research into lipid metabolism and cardiovascular disease. Its oral bioavailability enhances its utility in pharmacological studies related to lipid disorders.
In stock View Details -
- Cat. No.
- A76645
Granotapide
Synonyms: JTT-130
Granotapide is an orally active microsomal triglyceride transfer protein (MTP) inhibitor. By inhibiting MTP, Granotapide effectively reduces the absorption of cholesterol and triglycerides, making it a valuable tool for studying dyslipidemia. This compound is primarily utilized in research applications focused on lipid metabolism and associated disorders.
In stock View Details -
- Cat. No.
- A76646
Implitapide Racemate
Implitapide Racemate is a microsomal triglyceride transfer protein (MTP) inhibitor. By inhibiting MTP, it plays a crucial role in lipid metabolism, leading to decreased triglyceride levels in circulation. This compound is primarily utilized in research related to metabolic diseases and lipid disorders, aiding in the understanding of MTP's role in cardiovascular health and potential therapeutic interventions.
In stock View Details -
- Cat. No.
- A76647
CP-319340free base
CP-319340 free base is an inhibitor of microsomal triglyceride transfer protein (MTP), which plays a critical role in lipid metabolism. By inhibiting MTP, this compound reduces the transfer of triglycerides, leading to decreased apolipoprotein B-containing lipoprotein assembly and secretion. CP-319340 is primarily utilized in research applications focused on metabolic disorders, particularly those associated with dyslipidemia and cardiovascular disease.
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