Lanabecestat

Catalog No.: A12282

BACE1 inhibitor

Lanabecestat

Lanabecestat Chemical Structure

CAS NO. 1383982-64-6

Lanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM.

Availability: In stock

Package Price Qty
2 mg
$108.00
5 mg
$216.00
10 mg
$420.00
50 mg
$1,236.00
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Biological Activity

Lanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM.
In vitro DMSO 80 mg/mL (193.92 mM)
Water Insoluble
Ethanol 80 mg/mL (193.92 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.24 mL 121.2 mL 242.41 mL
0.5 mM 4.85 mL 24.24 mL 48.48 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL

*The above data is based on the productmolecular weight 412.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12282
Actions Inhibitor
CAS No. 1383982-64-6
Formula C26H28N4O
M. Wt 412.53
Purity >98%
Synonyms AZD 3293, AZD-3293, AZD3293; LY3314814, LY-3314814, LY 3314814
SMILES CC#CC1=CC(C2=CC([[email protected]@]34N=C(C)C(N)=N4)=C(C[[email protected]@]53CC[[email protected]@H](OC)CC5)C=C2)=CN=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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