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Lanadelumab
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody specifically targeting plasma kallikrein (pKal), exhibiting a potent inhibitory constant (Ki) of 0.12 nM. This antibody is capable of inhibiting both free and high molecular weight kininogen (HMWK)-bound forms of pKal. Lanadelumab is primarily utilized in research focused on hereditary angioedema, offering significant potential for elucidating the pathophysiology and therapeutic targeting of this condition.
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Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1426055-14-2 |
| Molecular Weight | 145720 |
| Synonyms | SHP643; DX-2930 |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.