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Biological Activity
PF-3187207 is a a nitric oxide (NO)-donating latanoprost with prostaglandin activity. It loweres intraocular pressure (IOP) more effectively than latanoprost in monkeys, dogs and rabbits.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.7 mL | 98.5 mL | 197 mL |
| 0.5 mM | 3.94 mL | 19.7 mL | 39.4 mL |
| 1 mM | 1.97 mL | 9.85 mL | 19.7 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
*The above data is based on the productmolecular weight 507.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18242 |
|---|---|
| CAS No. | 860005-21-6 |
| Formula | C27H41NO8 |
| M. Wt | 507.62 |
| Purity | >98% |
| Synonyms | PF-3187207; PF3187207; PF 3187207; Latanoprostene BUNOD; BOL-303259-X; NCX-116; NCX116; NCX116; |
| SMILES | O=C(OCCCCO[N+]([O-])=O)CCC/C=C\C[[email protected]@H]1[[email protected]@H](CC[[email protected]@H](O)CCC2=CC=CC=C2)[[email protected]](O)C[[email protected]@H]1O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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