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Fig. 1 · Structure
Cat. No.
A22394
CAS No.
2348-82-5
Formula
C11H8O3
Mol. Weight
188.18

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Lawsone methyl ether

antibacterial agent

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A549 IC50 16.4 μM Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay [PMID: 31563013]
HL-60 IC50 7.1 μM Cytotoxicity against human HL60 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay [PMID: 31563013]
Jurkat IC50 16.1 μM Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay [PMID: 31563013]
LS174T IC50 33.7 μM Cytotoxicity against human LS174T cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay [PMID: 31563013]
MCF7 IC50 6.1 μM Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay [PMID: 31563013]
MONO-MAC-6 IC50 4.8 μM Cytotoxicity against human MONO-MAC-6 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay [PMID: 31563013]
MRC5 IC50 5.2 μM Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 48 hrs by alamar blue assay [PMID: 26638044]
PBMC IC50 29.8 μM Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay [PMID: 31563013]
SMMC-7721 IC50 4.3 μM Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay [PMID: 21973054]
SW982 IC50 29.8 μM Cytotoxicity against human SW982 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay [PMID: 31563013]
THP-1 IC50 16.6 μM Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay [PMID: 31563013]
U-937 IC50 13.9 μM Cytotoxicity against human U937 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay [PMID: 31563013]
Vero CC50 13.02 μM Cytotoxicity against african green monkey Vero cells after 72 hrs by spectrophotometric analysis [PMID: 22795899]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 2348-82-5
Applications antibacterial agent
Formula C11H8O3
Molecular Weight 188.18
Synonyms 2-Methoxy-1,4-naphthoquinone
SMILES
O=C1C(OC)=CC(C2=C1C=CC=C2)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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