Fig. 1 · Structure
Documents & Downloads
LB42908
FTase Inhibitor
LB42908 is a potent, selective, and orally active farnesyltransferase inhibitor, primarily targeting the farnesylation process of H-Ras and K-Ras. It demonstrates remarkable inhibition with IC50 values of 0.9 nM for H-Ras and 2.4 nM for K-Ras, contributing to its significant antiproliferative properties. LB42908 is particularly relevant in cancer research, showcasing antitumor activity and providing a valuable tool for investigating the role of farnesylation in oncogenic signaling pathways.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 226927-89-5 |
| Applications | FTase Inhibitor |
| Formula | C32H31N5O3 |
| Molecular Weight | 533.62 |
| SMILES | O=C(C1=CN(CC2=CN=CN2CC3=CC=C(OCO4)C4=C3)C=C1C5=C6C=CC=CC6=CC=C5)N7CCN(C)CC7 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.