LC-SMCC

Catalog No.: A43103
ADC Linker
LC-SMCC is a versatile ADC linker that facilitates the conjugation of drugs to antibodies, enabling the development of antibody-drug conjugates (ADCs). Its primary mechanism involves the formation of stable thioether bonds through the reaction with thiol groups on the antibody. This compound is crucial for enhancing targeted delivery and efficacy of therapeutic agents while minimizing systemic toxicity, making it an essential tool in cancer research and drug development.
Grouped product items
Size Price Stock Qty
5mg
$105.00
In stock
10mg
$170.00
In stock
25mg
$340.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLC-SMCC is a versatile ADC linker that facilitates the conjugation of drugs to antibodies, enabling the development of antibody-drug conjugates (ADCs). Its primary mechanism involves the formation of stable thioether bonds through the reaction with thiol groups on the antibody. This compound is crucial for enhancing targeted delivery and efficacy of therapeutic agents while minimizing systemic toxicity, making it an essential tool in cancer research and drug development.
Product Information
Catalog NumA43103
FormulaC22H29N3O7
Molecular Weight447.48
CAS Number125559-00-4
SMILESO=C(CC1)N(OC(CCCCCNC(C2CCC(CN(C(C=C3)=O)C3=O)CC2)=O)=O)C1=O
SynonymsSuccinimidyl-[4-(N-maleimidomethyl)]-cyclohexane-1-carboxy-(6-amidocaproate)
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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    C2

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