Fig. 1 · Structure
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LC3B recruiter 2
LC3B Recruiter
LC3B Recruiter 2 is an autophagy-targeting compound designed to recruit LC3B proteins, integral to the autophagy-lysosome degradation pathway. This reagent binds to the CDK9 inhibitor SNS-032 via a linker, facilitating the targeted degradation of the CDK9-Cyclin T1 complex. By leveraging the LC3B-dependent autophagy mechanism, LC3B Recruiter 2 disrupts the cell cycle in cancer cells, demonstrating potential antitumor effects. This compound is valuable for research applications focused on autophagy modulation and cancer therapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 380636-64-6 |
| Applications | LC3B Recruiter |
| Formula | C10H9ClN2O2 |
| Molecular Weight | 224.64 |
| SMILES | CCN1C(NC2=CC(Cl)=CC=C2C1=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.