LCB-2122 is a nucleoside analogue that mimics adenosine and features a C2'-stereogenic all-carbon quaternary center. This compound exhibits protective effects against Doxorubicin-induced apoptosis in cardiomyocytes with an IC50 of 0.5 μM and also mitigates apoptosis induced by Imatinib. LCB-2122 activates AMPK signaling pathways, promoting the phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC), while reducing mitochondrial damage linked to Doxorubicin treatment. Its biological activities make LCB-2122 a valuable reagent for investigating mechanisms related to heart failure.
LCB-2122 is a nucleoside analogue that mimics adenosine and features a C2'-stereogenic all-carbon quaternary center. This compound exhibits protective effects against Doxorubicin-induced apoptosis in cardiomyocytes with an IC50 of 0.5 μM and also mitigates apoptosis induced by Imatinib. LCB-2122 activates AMPK signaling pathways, promoting the phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC), while reducing mitochondrial damage linked to Doxorubicin treatment. Its biological activities make LCB-2122 a valuable reagent for investigating mechanisms related to heart failure.
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