Fig. 1 · Structure
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LDN-91946
UCH-L1 Inhibitor
LDN-91946 is a selective, uncompetitive inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) with an apparent Ki of 2.8 μM. It effectively modulates UCH-L1 activity, making it a valuable tool for research into the regulation of protein degradation and cellular homeostasis. This compound supports investigations into neurodegenerative diseases and cancer, where UCH-L1 plays a significant role in protein turnover and stress response mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 439946-22-2 |
| Applications | UCH-L1 Inhibitor |
| Formula | C15H10N2O4S |
| Molecular Weight | 314.32 |
| SMILES | OC(C1=CC2=C(SC(C(C3=CC=CC=C3)=O)=C2N)NC1=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.