LEB-03-146 is a WEE1 deubiquitinase-targeting chimera (DUBTAC) that conjugates the potent inhibitor AZD1775 (Adavosertib) with the recruiter EN523 via a PEG2 linker. This compound effectively stabilizes WEE1 in HEP3B hepatoma cancer cells, making it a valuable tool for research into cell cycle regulation and cancer therapy. Its unique mechanism of action offers potential for novel therapeutic strategies in oncology.
LEB-03-146 is a WEE1 deubiquitinase-targeting chimera (DUBTAC) that conjugates the potent inhibitor AZD1775 (Adavosertib) with the recruiter EN523 via a PEG2 linker. This compound effectively stabilizes WEE1 in HEP3B hepatoma cancer cells, making it a valuable tool for research into cell cycle regulation and cancer therapy. Its unique mechanism of action offers potential for novel therapeutic strategies in oncology.
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