Lerimazoline is a selective agonist of the 5-HT1D receptor, exhibiting Ki values of 72 nM and 3480 nM for h5-HT1D and h5-HT1B receptors, respectively. This compound effectively inhibits Forskolin-induced cAMP production and stimulates contractions in rabbit saphenous vein preparations. Lerimazoline's pharmacological profile makes it a valuable tool for research into migraine pathophysiology and related therapeutic strategies.
Lerimazoline is a selective agonist of the 5-HT1D receptor, exhibiting Ki values of 72 nM and 3480 nM for h5-HT1D and h5-HT1B receptors, respectively. This compound effectively inhibits Forskolin-induced cAMP production and stimulates contractions in rabbit saphenous vein preparations. Lerimazoline's pharmacological profile makes it a valuable tool for research into migraine pathophysiology and related therapeutic strategies.
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