Fig. 1 · Structure
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Levocabastine hydrochloride
VLA-4 Antagonist
Levocabastine hydrochloride is a selective VLA-4 antagonist that effectively interferes with eosinophil infiltration in allergic conjunctivitis. Its primary mechanism involves blocking the binding of VLA-4, thereby reducing inflammatory responses in allergic conditions. Additionally, Levocabastine is noted for its high affinity for the neurotensin receptor subtype 2 (NTR2), making it a valuable tool in research focused on histamine-related pathways and allergy mechanisms. This compound is useful in the study of inflammatory diseases and the development of targeted therapies for allergy treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 79547-78-7 |
| Applications | VLA-4 Antagonist |
| Formula | C26H30ClFN2O2 |
| Molecular Weight | 456.98 |
| Synonyms | R 50547 hydrochloride |
| SMILES | OC([C@@]1(C2=CC=CC=C2)[C@@H](CN([C@]3([H])CC[C@](CC3)(C4=CC=C(C=C4)F)C#N)CC1)C)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.