Fig. 1 · Structure
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LG190178
VDR Ligand
LG190178 is a non-steroidal ligand for the vitamin D receptor (VDR), acting to induce heterodimer formation between VDR and retinoid X receptor (RXR). This stabilizes the agonistic conformation of the VDR ligand-binding domain, enhancing interactions with co-activators. Its biological activity impacts calcium homeostasis, bone mineralization, and cellular processes such as proliferation, differentiation, and apoptosis, making LG190178 a valuable tool for research into conditions like psoriasis, osteoporosis, and cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 233268-81-0 |
| Applications | VDR Ligand |
| Formula | C28H42O5 |
| Molecular Weight | 458.63 |
| SMILES | OCC(O)COC1=CC=C(C(C2=CC=C(OCC(O)C(C)(C)C)C(C)=C2)(CC)CC)C=C1C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.