Fig. 1 · Structure
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Liafensine
Monoamine Reuptake Inhibitor
Liafensine is a potent triple monoamine reuptake inhibitor (TRI) that targets dopamine, serotonin, and norepinephrine transporters with respective IC50 values of 5.67 nM, 1.08 nM, and 7.99 nM. This compound demonstrates significant antidepressant activity, making it a valuable tool for research in mood disorders and neuropharmacology. Its ability to modulate multiple neurotransmitter systems highlights its potential for exploring therapeutic strategies in depressive and anxiety disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1198790-53-2 |
| Applications | Monoamine Reuptake Inhibitor |
| Formula | C24H22N4 |
| Molecular Weight | 366.46 |
| Synonyms | BMS-820836 |
| SMILES | NC1=NN=C(C2=CC3=C(C=C2)[C@H](C4=CC=C5C=CC=CC5=C4)CN(C)C3)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.