Fig. 1 · Structure
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Lobeline
nAChR Agonist
Lobeline is a potent nicotinic acetylcholine receptor (nAChR) agonist that effectively penetrates the blood-brain barrier. By inhibiting dopamine (DA) uptake into synaptic vesicles and altering presynaptic DA storage, Lobeline enhances DA release. It is primarily utilized in research focused on addiction and smoking cessation, making it a valuable reagent in the study of dopaminergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 90-69-7 |
| Applications | nAChR Agonist |
| Formula | C22H27NO2 |
| Molecular Weight | 337.46 |
| Synonyms | α-Lobeline; L-Lobeline |
| SMILES | CN1[C@@H](CC(C2=CC=CC=C2)=O)CCC[C@H]1C[C@H](O)C3=CC=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.