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Lorlatinib impurity-1

Lorlatinib Intermediate

Lorlatinib impurity-1 is a critical intermediate in the synthesis of Lorlatinib, a potent inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1). This compound is essential for the production of Lorlatinib, which is employed in the treatment of various cancers, including non-small cell lung cancer (NSCLC) driven by ALK mutations. Its role as a synthetic precursor facilitates research and development in targeted cancer therapies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1455009-85-4
Applications	Lorlatinib Intermediate
Formula	C₂₁H₂₁FN₆O₃
Molecular Weight	424.43
SMILES	O=C(O)C1=CC=C(F)C=C1[C@H](OC2=CC(C3=C(C#N)N(C)N=C3CNC)=CN=C2N)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.