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LRH-0003

Mac1 Inhibitor

LRH-0003 is a selective inhibitor of Macrodomain 1 (Mac1) within the nonstructural protein 3 (NSP3) of SARS-CoV-2, demonstrating an IC50 value of 1.7 μM. This compound is essential for investigations into antiviral strategies against SARS-CoV-2, facilitating research on the molecular mechanisms underlying viral replication and pathogenesis. Its inhibition of Mac1 provides a significant avenue for developing therapeutic approaches targeting coronavirus infections.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2871220-06-1
Applications	Mac1 Inhibitor
Formula	C₁₄H₁₂FN₅O
Molecular Weight	285.28
SMILES	O=C1N(CCC1)NC2=NC=NC3=C2C4=CC=C(F)C=C4N3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.