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Form	MW
LSD1-IN-49 This page	382.50
LSD1-IN-49 hydrochloride	418.96

LSD1-IN-49

LSD1/KDM1A Inhibitor

LSD1-IN-49 is a potent inhibitor of Lysine-specific demethylase 1 (LSD1/KDM1A), exhibiting an IC50 of 29 nM in human cells. This compound irreversibly inhibits LSD1 activity by forming a stable adduct with the flavin adenine dinucleotide (FAD) cofactor, which is essential for its enzymatic function. LSD1-IN-49 serves as a valuable lead compound for the design of LSD1-targeted PET imaging agents, facilitating research in neurobiology and epigenetic regulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1422533-70-7
Applications	LSD1/KDM1A Inhibitor
Formula	C₂₆H₂₆N₂O
Molecular Weight	382.50
SMILES	O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC(C=C3)=CC=C3[C@H](C4)[C@@H]4NCC5CC5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.