Fig. 1 · Structure
Documents & Downloads
Lufotrelvir
3CLpro Protease Inhibitor
Lufotrelvir is a potent inhibitor of the SARS-CoV-2 3CLpro protease (Mpro), functioning as a phosphate proagent of PF-00835231. It demonstrates significant antiviral activity against SARS-CoV-2 with an inhibition constant (Ki) of 174 nM. Lufotrelvir serves as a valuable single-agent antiviral and is also suitable for research involving combination therapies with other antivirals that target various stages of the coronavirus life cycle.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2468015-78-1 |
| Applications | 3CLpro Protease Inhibitor |
| Formula | C24H33N4O9P |
| Molecular Weight | 552.51 |
| Synonyms | PF-07304814 |
| SMILES | COC1=C(C=C2C(N[C@@H](CC(C)C)C(N[C@H](C(CO[P](O)(O)=O)=O)C[C@H](CCN3)C3=O)=O)=O)C(N2)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.