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LWG-301

Glutaminase Inhibitor

LWG-301 is an allosteric inhibitor of Glutaminase 1 (GLS1), exhibiting an IC50 value of 7 nM. This compound effectively inhibits glutamine metabolism, leading to increased intracellular reactive oxygen species (ROS) and subsequent induction of apoptosis. LWG-301 demonstrates moderate antitumor activity in HCT116 xenograft models, making it a valuable tool for cancer research focusing on metabolic pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3038480-88-2
Applications	Glutaminase Inhibitor
Formula	C₂₈H₃₈N₈O₃S
Molecular Weight	566.72
SMILES	CCCCOC1=CC=CC(CC(NC2=NN=C(C=C2)N3CCC(CC3)NC4=NN=C(S4)NC(CCCC)=O)=O)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.