Fig. 1 · Structure
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LXQ46
PTP1B Inhibitor
LXQ46 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), with an IC50 value of 0.190 μM. This compound has been shown to enhance insulin and leptin signaling pathways in insulin-resistant C2C12 cells, demonstrating its ability to improve metabolic function. LXQ46 has potential applications in type 2 diabetes research, evidenced by its effectiveness in increasing insulin tolerance in various mouse models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2097148-94-0 |
| Applications | PTP1B Inhibitor |
| Formula | C23H17Br2NO5 |
| Molecular Weight | 547.19 |
| SMILES | BrC1=C(O)C(O)=CC(C2=NC=C(C3=CC=C(OC4=CC=C(C=C4)OCC)C=C3)O2)=C1Br |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.