Fig. 1 · Structure
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LY2365109
GlyT1 Inhibitor
LY2365109 is a selective glycine transporter 1 (GlyT1) inhibitor, exhibiting an IC50 of 15.8 nM for glycine uptake in cells over-expressing human GlyT1a. This compound plays a critical role in modulating glycine signaling pathways, making it valuable for research in neuropharmacology and the study of psychiatric disorders. Its specificity and potency facilitate investigations into the therapeutic potential of GlyT1 inhibition in various neurological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 868265-28-5 |
| Applications | GlyT1 Inhibitor |
| Formula | C22H27NO5 |
| Molecular Weight | 385.45 |
| SMILES | O=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.