LY314228 is a selective 5-HT2 antagonist primarily targeting the 5-HT2A receptor, exhibiting an IC50 of 147.9 nM. With Ki values of 65 nM for 5-HT2A, 1214 nM for 5-HT2B, and 168 nM for 5-HT2C, it demonstrates relative selectivity within the serotonin receptor family. This compound effectively inhibits 5-HT-induced paw edema in ovariectomized female rats, with an ED50 of 6.4 mg/kg, and can serve as a valuable tool for research in neuropharmacology and related fields.
LY314228 is a selective 5-HT2 antagonist primarily targeting the 5-HT2A receptor, exhibiting an IC50 of 147.9 nM. With Ki values of 65 nM for 5-HT2A, 1214 nM for 5-HT2B, and 168 nM for 5-HT2C, it demonstrates relative selectivity within the serotonin receptor family. This compound effectively inhibits 5-HT-induced paw edema in ovariectomized female rats, with an ED50 of 6.4 mg/kg, and can serve as a valuable tool for research in neuropharmacology and related fields.
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