LY320954 is a selective antagonist of the 5-HT2A receptor, exhibiting a Ki value of 96 nM. This compound effectively diminishes Ca2+ influx in cellular assays, demonstrating an EC50 of 35.5 nM. Additionally, LY320954 has shown significant efficacy in vivo by reducing 5-HT-induced paw swelling in rat models, with an ED50 of 4.8 mg/kg. This makes it a valuable tool for research into psychiatric disorders and the role of serotonergic signaling.
LY320954 is a selective antagonist of the 5-HT2A receptor, exhibiting a Ki value of 96 nM. This compound effectively diminishes Ca2+ influx in cellular assays, demonstrating an EC50 of 35.5 nM. Additionally, LY320954 has shown significant efficacy in vivo by reducing 5-HT-induced paw swelling in rat models, with an ED50 of 4.8 mg/kg. This makes it a valuable tool for research into psychiatric disorders and the role of serotonergic signaling.
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