Fig. 1 · Structure
Documents & Downloads
LY3526318
Cat. No.
A68748
CAS
1889218-34-1
TRPA1 Antagonist
LY3526318 is a selective antagonist of the TRPA1 ion channel, with an IC50 of 5-6 μM. This compound effectively inhibits TRPA1-mediated pain signal transduction, demonstrating notable analgesic activity. LY3526318 is primarily utilized in research focused on chronic pain conditions, including diabetic peripheral neuropathy, chronic low back pain, and osteoarthritis-related pain.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1889218-34-1 |
| Applications | TRPA1 Antagonist |
| Formula | C23H19F3N10O4 |
| Molecular Weight | 556.46 |
| SMILES | FC(F)(F)C1=NC=C(C=N1)C2=NC(NC([C@@H](N3C4=C(N=C3)N(C(N(C4=O)CC5=NC(C)=NO5)=O)C)C)=O)=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.