LY367385 is a highly selective antagonist of the metabotropic glutamate receptor 1a (mGluR1a). This compound demonstrates an IC50 of 8.8 μM in inhibiting quisqualate-induced phosphoinositide hydrolysis, showcasing its potency in modulating mGluR1a activity. LY367385 has been investigated for its neuroprotective, anticonvulsant, and antiepileptic effects, making it a valuable reagent for research in neuropharmacology and epilepsy studies.
LY367385 is a highly selective antagonist of the metabotropic glutamate receptor 1a (mGluR1a). This compound demonstrates an IC50 of 8.8 μM in inhibiting quisqualate-induced phosphoinositide hydrolysis, showcasing its potency in modulating mGluR1a activity. LY367385 has been investigated for its neuroprotective, anticonvulsant, and antiepileptic effects, making it a valuable reagent for research in neuropharmacology and epilepsy studies.
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