Fig. 1 · Structure
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LY367385
mGluR1a Antagonist
LY367385 is a highly selective antagonist of the metabotropic glutamate receptor 1a (mGluR1a). This compound demonstrates an IC50 of 8.8 μM in inhibiting quisqualate-induced phosphoinositide hydrolysis, showcasing its potency in modulating mGluR1a activity. LY367385 has been investigated for its neuroprotective, anticonvulsant, and antiepileptic effects, making it a valuable reagent for research in neuropharmacology and epilepsy studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 198419-91-9 |
| Applications | mGluR1a Antagonist |
| Formula | C10H11NO4 |
| Molecular Weight | 209.20 |
| SMILES | OC([C@H](C1=C(C=C(C(O)=O)C=C1)C)N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.