LY487379 hydrochloride is a selective positive allosteric modulator (PAM) of the human mGluR2 receptor. It enhances glutamate-stimulated [35S]GTPγS binding, exhibiting an EC50 value of 1.7 μM for mGluR2, and shows significantly lower activity at mGlu3 receptors. This compound has demonstrated potential in promoting cognitive flexibility and facilitating behavioral inhibition in rat models, making it a valuable reagent for schizophrenia research and the study of related neuropsychiatric disorders.
LY487379 hydrochloride is a selective positive allosteric modulator (PAM) of the human mGluR2 receptor. It enhances glutamate-stimulated [35S]GTPγS binding, exhibiting an EC50 value of 1.7 μM for mGluR2, and shows significantly lower activity at mGlu3 receptors. This compound has demonstrated potential in promoting cognitive flexibility and facilitating behavioral inhibition in rat models, making it a valuable reagent for schizophrenia research and the study of related neuropsychiatric disorders.
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