Fig. 1 · Structure
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LY487379
mGluR2 PAM
LY487379 is a selective positive allosteric modulator (PAM) of the human metabotropic glutamate receptor 2 (mGluR2). It enhances glutamate-stimulated [35S]GTPγS binding with an EC50 of 1.7 μM for mGluR2 and >10 μM for mGluR3. LY487379 has been demonstrated to promote cognitive flexibility and facilitate behavioral inhibition in rat models, making it a valuable tool for schizophrenia research and the exploration of neuropsychological mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 353231-17-1 |
| Applications | mGluR2 PAM |
| Formula | C21H19F3N2O4S |
| Molecular Weight | 452.45 |
| SMILES | FC(F)(F)CS(=O)(N(C1=CC=C(OC2=CC=CC=C2OC)C=C1)CC3=CC=CN=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.