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Fig. 1 · Structure
Cat. No.
A22170
CAS No.
476-28-8
Formula
C16H17NO4
Mol. Weight
287.31

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Lycorine

Cat. No. A22170 CAS 476-28-8

SCAP inhibitor

Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A2780 IC50 0.3 μM Cytotoxicity against human A2780 cells assessed as cell growth inhibition incubated for 48 hrs by WST-1 assay [PMID: 34536668]
A-431 ED50 1.3 μg/mL Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay [PMID: 8229016]
A549 IC50 0.3 μM Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by WST-1 assay [PMID: 34536668]
A549 GI50 0.9 μM Growth inhibition of pro-apoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay [PMID: 22019045]
A549 IC50 1.9 μM Cytotoxicity against human A549 cells after 48 hrs by MTT assay [PMID: 23190013]
A549 IC50 2 μM Growth inhibition of apoptosis-resistant human A549 cells after 72 hrs by MTT assay [PMID: 20415482]
A549 GI50 3 μM Growth inhibition of human A549 cells by MTT assay [PMID: 24393582]
A549 IC50 4.2 μM Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay [PMID: 20550100]
A549 IC50 4.3 μM Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay [PMID: 19788245]
AGS IC50 0.3 μM Cytotoxicity against human AGS cells assessed as cell growth inhibition incubated for 48 hrs by WST-1 assay [PMID: 34536668]
B16-F10 GI50 2 μM Growth inhibition of pro-apoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay [PMID: 22019045]
B16-F10 IC50 2 μM Growth inhibition of apoptosis-sensitive mouse B16F10 cells after 72 hrs by MTT assay [PMID: 20415482]
B16-F10 GI50 2.6 μM Growth inhibition of mouse B16F10 cells by MTT assay [PMID: 24393582]
B16-F10 IC50 6.3 μM Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay [PMID: 19788245]
B16-F10 IC50 6.3 μM Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay [PMID: 20550100]
BEAS-2B IC50 4.9 μM Cytotoxicity against human BEAS2B cells after 48 hrs by MTT assay [PMID: 23190013]
BHK-21 CC50 4.37 μM cytotoxicity against golden hamster BHK-21 cells incubated for 72 hrs by MTT assay [PMID: 32845145]
BJ IC50 1.9 μM Cytotoxicity against human BJ cells after 72 hrs by Calcein AM assay [PMID: 22921081]
BT-549 IC50 0.3 μM Cytotoxicity against human BT-549 cells assessed as cell growth inhibition incubated for 48 hrs by WST-1 assay [PMID: 34536668]
CCRF-CEM IC50 1.6 μM Cytotoxicity against human CEM cells after 72 hrs by Calcein AM assay [PMID: 22921081]

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 476-28-8
Applications SCAP inhibitor
Formula C16H17NO4
Molecular Weight 287.31
SMILES
O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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