Fig. 1 · Structure
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Lys-Des-Arg9Bradykinin TFA
Bradykinin B1 Receptor Agonist
Lys-[Des-Arg9]Bradykinin TFA is a selective agonist of the bradykinin B1 receptor, exhibiting high affinity with Ki values of 0.12 nM, 1.7 nM, and 0.23 nM for human, mouse, and rabbit B1 receptors, respectively. This compound demonstrates minimal inhibitory activity on B2 receptors, making it a valuable tool for studying the B1 receptor's role in inflammation and pain pathways. Its potent activity supports its use in various biological and pharmacological research applications focused on the modulation of kinin pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2763588-90-3 |
| Applications | Bradykinin B1 Receptor Agonist |
| Formula | C52H74F3N13O13 |
| Molecular Weight | 1146.22 |
| SMILES | OC(C(F)(F)F)=O.O=C(N1[C@@H](CCC1)C(NCC(N[C@H](C(N[C@@H](CO)C(N2[C@@H](CCC2)C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CC=CC=C4)=O)=O)[C@H]5N(CCC5)C([C@H](CCCNC(N)=N)NC([C@@H](N)CCCCN)=O)=O.OC(C(F)(F)F)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.