[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) is a selective agonist for the NK2 receptor (NK2R), exhibiting a potent EC50 of 3.7 nM for human NK2R. This compound has demonstrated significant biological activity by inhibiting weight loss in diet-induced obese mouse models and ameliorating Loperamide-induced voiding dysfunction in wild-type mice. It serves as a valuable tool for research into neurokinin receptor-mediated disorders, including obesity, insulin resistance, and type 2 diabetes.
[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) is a selective agonist for the NK2 receptor (NK2R), exhibiting a potent EC50 of 3.7 nM for human NK2R. This compound has demonstrated significant biological activity by inhibiting weight loss in diet-induced obese mouse models and ameliorating Loperamide-induced voiding dysfunction in wild-type mice. It serves as a valuable tool for research into neurokinin receptor-mediated disorders, including obesity, insulin resistance, and type 2 diabetes.
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