Fig. 1 · Structure
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m-PEG-OH (MW5000)
PROTAC Linkers
m-PEG-OH (MW5000) is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of PROTACs by providing a flexible and hydrophilic connector that enhances their solubility and stability. Its application is critical in drug discovery and development, particularly in studies focused on targeted protein degradation and modulation of protein levels in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 9004-74-4 |
| Applications | PROTAC Linkers |
| Molecular Weight | 5000(Average) |
| Synonyms | mPEG-Hydroxy (MW5000); Polyethylene glycol monomethyl ether (MW5000) |
| SMILES | COCCOCCO.[n].[MW 5000] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.