Fig. 1 · Structure
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m-PEG-thiol (MW 2000)
PROTAC Linkers
m-PEG-thiol (MW 2000) is a polyethylene glycol (PEG)-derived thiol that serves as a valuable linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides improved solubility and stability, enabling effective conjugation to E3 ligases and target proteins. Its applications are crucial in the development of PROTAC-based therapeutics, facilitating targeted degradation of proteins in research and drug discovery.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 134874-49-0 |
| Applications | PROTAC Linkers |
| Molecular Weight | 2000(Average) |
| Synonyms | mPEG-SH (MW 2000) |
| SMILES | COCCOCCS.[MW 2000].[n] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.