Fig. 1 · Structure
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m-PEG2-CH2CH2COOH
PROTAC Linker
m-PEG2-CH2CH2COOH is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound enhances solubility and promotes effective protein degradation by facilitating the conjugation of a target protein to E3 ligases. Its primary application lies in the development of new PROTAC molecules for targeted protein modulation in various biological research studies, including cancer and drug resistance investigations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 209542-49-4 |
| Applications | PROTAC Linker |
| Formula | C8H16O5 |
| Molecular Weight | 192.21 |
| SMILES | O=C(O)CCOCCOCCOC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.