Fig. 1 · Structure
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m-PEG5-SH
PROTAC Linkers
m-PEG5-SH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis targeting chimera) synthesis. It facilitates the formation of PROTACs by providing a flexible, hydrophilic spacer that enhances solubility and improves the efficacy of targeted protein degradation. This reagent is essential for researchers developing novel therapeutic strategies aimed at manipulating cellular protein turnover and studying protein interactions. Its application is pivotal in advancing the field of targeted protein degradation and drug discovery.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 524030-00-0 |
| Applications | PROTAC Linkers |
| Formula | C11H24O5S |
| Molecular Weight | 268.37 |
| SMILES | COCCOCCOCCOCCOCCS |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.