m-PEG9-azide serves as a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functionality that enables it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkynyl compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it a versatile tool for chemical biology applications, particularly in targeted protein degradation research.
m-PEG9-azide serves as a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functionality that enables it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkynyl compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it a versatile tool for chemical biology applications, particularly in targeted protein degradation research.
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