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MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.17 mL | 45.83 mL | 91.65 mL |
| 0.5 mM | 1.83 mL | 9.17 mL | 18.33 mL |
| 1 mM | 0.92 mL | 4.58 mL | 9.17 mL |
| 5 mM | 0.18 mL | 0.92 mL | 1.83 mL |
*The above data is based on the productmolecular weight 1091.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18403 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 1091.06 |
| Formula | C50H54N6O20S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 2246380-69-6 |
| SMILES | O=C([[email protected]@H]1[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)[[email protected]](OC2=CC=C(COC(N(COC3=CC=C4N=C5C(CN6C(C(COC([[email protected]@]7(CC)O)=O)=C7C=C65)=O)=C(CC)C4=C3)CCS(=O)(C)=O)=O)C=C2NC(CN(C)C(CCN8C(C=CC8=O)=O)=O)=O)O1)O |
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