Fig. 1 · Structure
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MAGL-IN-17
MAGL Inhibitor
MAGL-IN-17 is a potent inhibitor of monoacylglycerol lipase (MAGL) with an inhibition constant (Ki) of 0.4 μM. This compound demonstrates significant inhibitory effects on both mouse and rat MAGL, with IC50 values of 0.18 μM and 0.24 μM, respectively. MAGL-IN-17 also exhibits anti-inflammatory activity, making it suitable for research applications in models of autoimmune diseases, such as experimental autoimmune encephalitis in mice.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1643657-35-5 |
| Applications | MAGL Inhibitor |
| Formula | C26H26O4 |
| Molecular Weight | 402.48 |
| SMILES | O=C(CCCCCC1=CC=C(C2=CC=CC=C2)C=C1)OCC3=CC4=C(C=C3)OCO4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.